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dStruct: identifying differentially reactive regions from RNA structurome profiling data
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DOI：10.1186/s13059-019-1641-3.png)
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Abstract
En 中文
RNA biology is revolutionized by recent developments of diverse high-throughput technologies for transcriptome-wide profiling of molecular RNA structures. RNA structurome profiling data can be used to identify differentially structured regions between groups of samples. Existing methods are limited in scope to specific technologies and/or do not account for biological variation. Here, we present dStruct which is the first broadly applicable method for differential analysis accounting for biological variation in structurome profiling data. dStruct is compatible with diverse profiling technologies, is validated with experimental data and simulations, and outperforms existing methods.
Keywords:
RNA structure
Structure probing
Differential analysis
Transcriptome-wide profiling
SHAPE
DMS
PARS
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