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Dual faces of USP10 in breast cancer: Oncogenic driver, tumor suppressor, and emerging therapeutic target
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DOI：10.1016/j.biopha.2025.118916.png)
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Abstract
En 中文
• USP10 exhibits context-dependent oncogenic/tumor-suppressive roles in breast cancer via substrate deubiquitination. • USP10 modulates proliferation, metastasis, and immune evasion by targeting key pathways. • USP10 inhibition synergizes with PARP inhibitors, ADCs, and chemotherapy in preclinical breast cancer models. • USP10 represents a promising precision oncology target requiring subtype-specific strategies.
Keywords:
Breast cancer
USP10
Deubiquitination
Tumor suppressor
Oncogene
Therapeutic target
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