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Durability of Response to Icotrokinra in Adults With Moderate-to-Severe Plaque Psoriasis: One-Year Results From the Phase 3, Placebo- and Active Comparator-Controlled ICONIC-ADVANCE 1 & ICONIC-ADVANCE 2 Trials

delete2026-07-03
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OA
AI
L
Linda Stein Gold *
A
April W Armstrong
J
Jennifer Soung
R
Ronald B Vender
Á
Álvaro González Cantero
M
Matthias Hoffmann
S
Scott T Guenthner
H
H Chih-Ho Hong
D
Dedee F Murrell
E
Eingun James Song
L
Leon Kircik
M
Matthias Augustin
M
Maxwell Sauder
S
Sascha Gerdes
O
Ofelia Reyes-Servin
B
Bassey Effiom Edem
J
Jennifer Campbell
K
Kellen Cresswell
L
Lea Kephart
S
Shu Li
Y
Ya-Wen Yang
DOI:10.1093/bjd/ljag264delete
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Abstract

Abstract

En 中文
Icotrokinra, a targeted oral peptide, precisely blocks the interleukin-23 receptor. In two phase 3 moderate-to-severe plaque psoriasis trials, ICONIC-ADVANCE 1 (NCT06143878) and ICONIC-ADVANCE 2 (NCT06220604), icotrokinra provided significantly higher skin clearance rates versus placebo at Week 16 and deucravacitinib at Week 16 and 24.

Journal

British Journal of Dermatology cover
British Journal of Dermatology
IF:
9.6
Papers:
2.8W
Citations:
3.2W

Organization

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U
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U
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I
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Hospital Universitario Ramón y Cajal cover
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U
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