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Dynamic chemical bond-driven sustained release of GDN-PLGA microspheres in injectable composite hydrogels for enhanced wound healing
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DOI：10.1088/1748-605X/ae59dc.png)
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Abstract
En 中文
Traditional passive wound dressings struggle to meet the demands of effective wound management. This study developed an intelligent hydrogel composite wound dressing system with microenvironment-responsive characteristics, achieving controlled drug release by constructing a dynamic dual-network structure. Gastrodin-Poly (lactic-co-glycolic acid) (GDN-PLGA) drug-loaded microspheres, with a particle size of 20–80 μm and an encapsulation efficiency of 44.3 ± 2%, are co-loaded into the system, forming an injectable drug-loaded hydrogel (GOA-GDN-PLGA). The results demonstrated that the GOA-GDN-PLGA dual-network injectable hydrogel significantly promotes wound healing. In a rat full-thickness skin defect model, the treatment group achieved a healing rate of 85.4 ± 4% after 14 d, considerably better than the commercial dressing group (51 ± 2%, p<0.01). Histological analysis showed more organized collagen deposition and increased vascular density. These results indicate that the GOA-GDN-PLGA injectable drug-loaded hydrogel facilitates rapid hemostasis and enables controlled drug release, effectively addressing the challenge of multiple administrations of soluble drugs in traditional wound management.
Keywords:
Intelligent hydrogel composite
Controlled drug release
Wound healing
GDN-PLGA microspheres
Dual-network structure
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