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Dysregulated iron homeostasis Drives mitochondrial Injury and ferroptosis susceptibility in MELAS fibroblasts

delete2026-02-11
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PRE
AI
Y
Yu‐Han Lin
X
Xiao-Wen Wang
Y
Yuan Li
T
Ting-Ya Chen
W
Wei-Shiung Lian
F
Feng‐Sheng Wang
M
Min‐Yu Lan
C
Chia-Wei Liou
T
Tsu‐Kung Lin *
DOI：10.1016/j.mito.2026.102132delete
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Abstract

Abstract

En 中文
• Susceptibility to Ferroptosis: Rotenone triggers damage in MELAS fibroblasts, including elevated ROS, lipid peroxidation, and Fe2+—heteroplasmy-dependent. • MELASHi is more vulnerable: Baseline Fe2+↑ and GPX4/xCT↓ compared to MELASLow. • DFO (1–100 μM) rescues: Restores cell survival rate, curbs mitochondrial fragmentation.
Keywords:
ferroptosis
iron homeostasis
mitochondrial injury
MELAS fibroblasts
rotenone

Journal

MITOCHONDRION cover
MITOCHONDRION
IF:
4.5
Papers:
2.4K
Citations:
5.5K

Organization

C
chang gung memorial hospital
Scholars:
1.5W
Papers: 1.3W
Citations: 55
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