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Dysregulated selective translation in cancer: The pivotal functions of RNA-binding proteins and emerging therapeutic avenues
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DOI：10.1016/j.bbcan.2026.189602.png)
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Abstract
En 中文
• Selective translation of oncoproteins is an essential hallmark of cancers, facilitating rapid adaptation to various oncogenic cues and hostile insults. • Malignant cells reprogram translation by hijacking RNA-binding proteins (RBPs) to recognize specific cis-regulatory elements, orchestrating protein programs that drive tumorigenesis. • RNA-binding protein-mediated selective translation acts as a central regulatory hub that orchestrates core cancer hallmarks, including tumor growth, immune evasion, and therapy resistance. • Targeting selective translation represents a promising strategy for anti-cancer therapeutics.
Keywords:
Selective translation
RNA-binding proteins
Oncoproteins
Tumorigenesis
Therapeutic targeting
Journal
B
IF:
0
Papers:
105
Citations:
0
Organization
Cited Papers