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Dysregulation of circulating angiopoietins is associated with low birth weight in children who are HIV-exposed and uninfected

delete2026-05-01
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PRE
AI
J
Julia Sawatzky
A
Andrea L. Conroy
J
Jeanne Brochon
F
Fatima Kakkar
J
Jason Brophy
S
Sophie Namasopo
R
Robert Opoka
M
Michael Hawkes *
DOI:10.1097/QAD.0000000000004424delete
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Abstract

Abstract

En 中文
HIV exposure in utero is associated with low birth weight (LBW), even in the absence of vertical transmission. To explore mechanism, we evaluated endothelial markers angiopoietin (Ang)-1 and Ang-2 among 294 uninfected Ugandan infants born to women with HIV (WWH). The median Ang-2/Ang-1 ratio was 0.051 [interquartile range (IQR) 0.023-0.19] among infants with LBW and 0.018 (IQR 0.010-0.037) among controls (P = 0.00011). Endothelial dysregulation may contribute to LBW among infants born to WWH.
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indiana university system
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