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Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice
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DOI：10.1002/jcsm.70357.png)
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Abstract
En 中文
Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling within ALS skeletal muscle has never been studied. This study investigated temporal and muscle type–specific ECS changes in ALS.
Keywords:
ALS
cannabinoid receptor
endocannabinoid system
FAAH
neurodegeneration
SOD1
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