Early auditory processing dysfunction in schizophrenia: Mechanisms and implications

Clément Dondé

doi:10.1016/j.neubiorev.2023.105098

Early auditory processing dysfunction in schizophrenia: Mechanisms and implications

2023-05-01

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DOI：10.1016/j.neubiorev.2023.105098

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Schizophrenia is a major mental disorder that affects approximately 1% of the population worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long-term disability. Over the past decades, significant literature has accumulated demonstrating impairments in early auditory perceptual processes in schizophrenia. In this review, we first describe early auditory dysfunction in schizophrenia from both a behavioral and neurophysiological perspective and examine their interrelationship with both higher order cognitive constructs and social cognitive processes. Then, we provide insights into underlying pathological processes, especially in relationship to glutamatergic and N-methyl-D-aspartate receptor (NMDAR) dysfunction models. Finally, we discuss the utility of early auditory measures as both treatment targets for precision inter-vention and as translational biomarkers for etiological investigation. Altogether, this review points out the crucial role of early auditory deficits in the pathophysiology of schizophrenia, in addition to major implications for early intervention and auditory-targeted approaches.

Keywords:

Schizophrenia

Auditory

Tone-matching

Event-related potentials

NMDA receptor

Early auditory processing dysfunction in schizophrenia: Mechanisms and implications

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