1
Return

Early-life immune imprinting by a B. infantis-HMO synbiotic shapes infant immune signatures and protects against experimental respiratory disease

delete2026-07-31
delete0
delete
OA
AI
R
Ridwan B. Rashid
C
Cheong Kwong Chung
P
Patricia Namubiru
T
Tufael Ahmed
D
Daniel R. Howard
I
Ismail Sebina
T
Tyler Wilkins
M
Md. Sohel Rana
J
Joshua P. Morrow
D
Darren J. Creek
J
Janne Marie Moll
K
Karine Vidal
C
Cecilia Fumero
L
Luca Lavalle
D
Dominick Maes
N
Nicholas P. Hays
I
Irma Silva‐Zolezzi
E
Elizabeth Forbes-Blom
N
Norbert Sprenger
J
Jean-Charles Picaud
DOI：10.1016/j.xcrm.2026.102935delete
deleteOriginal
deleteShare
deleteSave
View PDF
Abstract

Abstract

En 中文
• Synbiotic supplementation reduces Th2 abundance in infant blood • Synbiotic protects neonatal mice from sLRI and confers lasting immune benefits • Synbiotic increases 12-HHT, linked to improved infection outcomes • Oral 12-HHT supplementation phenocopies synbiotic-mediated protection from sLRI
Keywords:
synbiotic
infant-type bifidobacteria
B. infantis
HMOs
breastfeeding
bronchiolitis
RSV
asthma
immune imprinting
microbiome-host interactions
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

Organization

No organization information available
Cited Papers

Cited Papers

Citing Papers

Citing Papers