ECM-inspired mechanically robust hydrogels for diabetic wound regeneration

Salim Ullah

doi:10.1016/j.ccr.2025.217456

ECM-inspired mechanically robust hydrogels for diabetic wound regeneration

2025-12-10

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DOI：10.1016/j.ccr.2025.217456

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• EMHG blend electrospun nanofibers with hydrogels to mimic native skin topology, boosting cell attachment, proliferation, and diabetic wound healing. • EMHG integrates polymer fibers and hydrogel, providing exceptional mechanical strength, elasticity, and water retention for withstanding wound environments. • Coaxial electrospinning and 3D printing provide exact control of EMHG's structure, porosity, and drug delivery, facilitating hemostatic and anti-inflammatory therapies. • Bioactive material-loaded EMHG promotes angiogenesis, fights infections, and modulates immunity, solving chronic inflammation and delayed healing in diabetic wounds. • EMHG solves toxicity and adaptability challenges in tissue engineering, creating smart materials for better diabetic wound care and reduced healthcare burdens.

ECM-inspired mechanically robust hydrogels for diabetic wound regeneration

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