.png){kind=icon}
.png){kind=icon}
Return
Effects and Mechanisms of Nobiletin on Gut Motility by Coordinating Bile Acid Signaling via Dual Ileal-Colonic Axes in STC Model Mice
.png){kind=icon}
PRE
AI
D
H
H
X
B
Y
Y
Q
DOI：10.1016/j.jnutbio.2026.110385.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Nobiletin alleviates slow-transit constipation by restoring gut barrier integrity and mucus secretion. • It modulates bile acid signaling via the FXR/TGR5-ASBT in ileum and FXR/TGR5-5-HT3R in colon. • Nobiletin remodels gut microbiota, reversing dysbiosis. • Treatment rebalances plasma neurotransmitters and enhances intestinal propulsion in constipated mice.
Keywords:
Nobiletin
gut motility
bile acid signaling
gut barrier integrity
constipation
Journal
T
IF:
0
Papers:
132
Citations:
0