.png){kind=icon}
.png){kind=icon}
Return
Effects of acute and long-term exercise modalities and doses on brain-derived neurotrophic factor in patients with stroke: a Bayesian network meta-analysis
.png){kind=icon}
OA
AI
H
Y
陈
DOI：10.3389/fnsys.2026.1905191.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
ObjectiveTo systematically evaluate the effects of exercise interventions on brain-derived neurotrophic factor (BDNF) in patients with stroke; and to examine the dose–response relationships associated with acute and long-term exercise.MethodsPubMed; Embase; Web of Science; the Cochrane Library; and APA PsycINFO were searched for studies of exercise interventions in patients with stroke that reported BDNF outcomes. Risk of bias was assessed using RoB 2.0 and ROBINS-I. A network dose–response meta-regression was conducted within a Bayesian random-effects framework.ResultsTwenty-three studies involving 903 participants were included; comprising 14 randomized controlled trials; 8 non-randomized studies; and 1 randomized crossover trial. Acute overall exercise showed a modest positive trend at lower dose levels; however; at a dose of 250 METs⋅min/week; the 95% credible interval included zero; indicating substantial uncertainty regarding whether a single bout of low-dose exercise produces a reliable increase in BDNF. For long-term overall exercise; posterior estimates generally favored a positive BDNF response as dose increased. The 95% credible interval first no longer included zero at 1300 METs⋅min/week; and estimates at 1700; 2000; 2300; and 2700 METs⋅min/week remained compatible with positive effects. However; these findings should be interpreted cautiously because the evidence base was limited and precision varied across dose levels. Clear differences were also observed across long-term exercise modalities. Multicomponent exercise showed the most favorable directional pattern across the 1700–2700 METs⋅min/week range; although several estimates were imprecise and the apparent advantage of this modality should be regarded as exploratory. By contrast; walking; cycling; and exercise combined with cognitive training all showed positive directional trends; but the 95% credible intervals included zero across dose levels; indicating substantial uncertainty regarding these modality-specific effects.ConclusionThe effects of exercise on BDNF in patients with stroke are jointly shaped by intervention duration; dose level; and exercise modality. Compared with acute exercise; long-term exercise at moderate-to-high doses; particularly multicomponent exercise; may be associated with a more favorable BDNF response. However; because the certainty of evidence was mostly moderate to low or very low and publication bias was detected; these findings should be considered preliminary and hypothesis-generating rather than definitive exercise prescription recommendations.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420261350793; identifier CRD420261350793.
Keywords:
exercise
stroke
neuroplasticity
brain-derived neurotrophic factor
dose–response relationship
Journal
IF:
3.5
Papers:
1.0K
Citations:
6.2K
Organization
Cited Papers