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Effects of Angelica archangelica Extract on Overactive Bladder: A Pilot Randomized Controlled Trial
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DOI：10.1002/fsn3.71258.png)
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Abstract
En 中文
Overactive bladder (OAB) is a prevalent syndrome affecting quality of life (QoL) in 10.8% of men and 12.8% of women in Europe, impacting various aspects of daily functioning. Conventional treatments like antimuscarinic drugs show low adherence due to limited efficacy and side effects. This study explores the effects of natural supplementation with Angelica archangelica (AA) leaf extract on OAB symptoms, focusing on daytime voids, nocturia, and urgency. A pilot study with a randomized, triple-blind, controlled trial design, registered on ClinicalTrials.gov (NCT04357223), was conducted with 143 participants assigned to AA (SUP) or placebo (PLA) groups in a 1.75:1 ratio over 6 weeks. Adults aged 18–75 with specific OAB symptoms were included. Data were securely managed via the RedCap platform. OAB symptomatology was assessed following the recommended tools and scales according to the Spanish Association of Urology guidelines: A 3-day voiding diary (3-dVD) and the International Prostate Symptom Score (IPSS). Additionally, the IPSS total score and IPSS storage subscore were measured. Statistical analysis was performed by SPSS, R, and Python. The Wilcoxon test was used to analyze pre-to-post differences, and linear mixed model analysis for group-by-time interactions. SUP showed significant improvements in daytime voids (p = 0.004; η2g = 0.07), IPSS storage subscore (p = 0.025; η2g = 0.05), and QoL (p < 0.001; η2g = 0.12), while a nearly significant improvement in nocturia was observed through IPSS results (p = 0.069; η2g = 0.03) compared with PLA. IPSS total score changes were clinically meaningful and higher in SUP (from 19.78 to 15.89) than in PLA (from 19.64 to 16.38). Adults with OAB syndrome significantly reduced daytime voids and IPSS storage subscore, improving QoL after AA supplementation for 6 weeks. Positive effects on nocturia were also observed.
Keywords:
clinical practice
health
natural supplementation
nocturia
overactive bladder
plant products
traditional medicine
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