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Effects of Head Group Substitution on Large Antiviral Polyamide-DNA Binding Kinetics
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DOI：10.1016/j.biochi.2026.04.006.png)
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Abstract
En 中文
• 20-ring polyamides with guanidinium and tetramethyl guanidine groups have been synthesized. • Head group substitutions significantly weaken DNA binding for the 20-ring hairpin polyamide. • Head group substitutions perturb microscopic binding kinetics but not antiviral activity.
Keywords:
polyamides
guanidinium
DNA binding
antiviral activity
binding kinetics
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