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Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
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DOI：10.1016/j.atherosclerosis.2025.120540.png)
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Abstract
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• High-dose vitamin K2+D3 improved dp-ucMGP and P-25-OH D but did not affect epicardial fat or inflammation. • Findings align with prior studies: even high-dose, long-term vitamins may not affect cardiovascular inflammation. • Cardiovascular inflammation involves complex mechanisms, and effective therapeutic modulation remains a challenge. • Advanced disease and methodological limits may require alternative strategies for effective reduction in inflammation.
Keywords:
Cardiac CT scan
Atherosclerosis
Inflammation
Vitamin K2
Vitamin D3
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