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Efficacy of Single and Fractionated Neutron Irradiation of Normal and Tumor Cells In Vitro

delete2026-04-01
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PRE
AI
K
Koryakina, E. V. *
P
Pichkunova, A. A.
T
Troshina, M. V.
P
Potetnya, V. I.
S
Saburov, V. O.
L
Litun, E. V.
L
Lychagin, A. A.
K
Koryakin, S. N.
DOI:10.1007/s10517-026-06639-4delete
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Abstract

Abstract

En 中文
We studied the effect of 14.5 MeV neutron dose ultrafractionation on survival and recovery kinetics from radiation damage in normal V-79 and tumor B14-150 cells. Neutron doses of 0.5, 2, 4, and 6 Gy were split into 1, 2, 3, and 4 fractions. The observed recovery times 1.6 h (V-79) and 0.94 h (B14-150) indicate the possibility of reducing radiation damage with increasing the number of fractions. It was shown that neutron irradiation efficacy decreases when intervals between fractions exceed 1 h.
Keywords:
fast neutrons
fractionated irradiation
normal cells
tumor cells
cell survival

Journal

B
Bulletin of Experimental Biology and Medicine
IF:
0.6
Papers:
167
Citations:
2.8K

Organization

M
ministry of health of the russian federation
Scholars:
4.0K
Papers: 1.5K
Citations: 6