.png){kind=icon}
.png){kind=icon}
Return
Efficiency of preparative and process column distribution systems
.png){kind=icon}
PRE
AI
DOI：10.1016/S0021-9673(03)00177-8.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
An analytical method for computing the residence time distribution of the liquid distribution system in chromatography columns is described. The impact of the distributor design on the separation efficiency is predicted as a function of media properties and packed bed dimensions. The efficiency loss due to the distributor when increasing column diameter during scale-up is quantified. It is shown that this loss can be compensated by modulating the local bed height via a moderate inclination of the bed support. It is concluded that the selection of an appropriate distributor design concept with optimised dimensions enables a scale-up of chromatographic separations without any significant loss of chromatographic efficiency due to the distribution system. (C) 2003 Elsevier B.V. All rights reserved.
Keywords:
residence time distribution
efficiency
preparative chromatography
distribution system
column packing
mathematical modelling
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
4
Papers:
3.2W
Citations:
5.0W
Organization
No organization information available