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Efficient Biosynthesis of γ-Aminobutyric Acid by a GadBD304G/F433L Mutant-based Whole- cell Biocatalyst

delete2026-02-09
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PRE
AI
M
Min Wu
F
Fei Tang
X
Xin Xu
H
Haoju Wang
Q
Qing Chen
W
Wei Sun
H
Huiru Cui
J
Jiahui Jiang
H
Hongguang Yang
P
Ping Yu*
M
Min Chen*
DOI：10.1016/j.bej.2026.110114delete
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Abstract

Abstract

En 中文
• gadC was cloned into pETDuet-1-gadBD304G/F433L to construct co-expressing strain. • Whole-cell biocatalysis was optimized by single-factor and orthogonal experiments. • 382.59 g/L GABA was produced by a whole-cell catalyst recycling for 5 batches. • This study contributes to the industrial production of GABA by engineered strain.
Keywords:
GABA
whole-cell biocatalysis
GadBD304G/F433L mutant
bioproduction
strain engineering

Journal

Biochemical Engineering Journal cover
Biochemical Engineering Journal
IF:
3.8
Papers:
6.2K
Citations:
1.4W

Organization

Z
Zhejiang Province
Scholars:
136
Papers: 57
Citations: 580
Z
zhejiang gongshang university
Scholars:
1.2K
Papers: 519
Citations: 0
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