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Eicosatrienoic acid improves PCOS in mice by modulating the intestinal barrier and ovarian inflammation

delete2026-07-29
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PRE
AI
J
Jin Yan
S
Shao-Zhuang Ma
S
Shuang-Yan Chang
Z
Zheng-Yun Jin
X
Xi-Xiu Liao
M
Ming-Xia Jia
J
Jin‐Dan Kang *
L
Lin‐Hu Quan *
DOI：10.1016/j.jnutbio.2026.110477delete
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Abstract

Abstract

En 中文
• Damaged gut barrier function, ovarian inflammation, and estradiol secretion disorder are observed in PCOS mice. • GLP-1 notably enhances the gut barrier function and alleviates ovarian inflammation. • ETA improves PCOS by regulating GLP-1 levels to restore the intestine and block the ovarian inflammation condition. • Reveal the mechanism by which GLP-1 affects PCOS dual-action for the first time.
Keywords:
polycystic ovary syndrome
eicosatrienoic acid
GLP-1
intestinal barrier
ovarian inflammation

Journal

Journal of Nutritional Biochemistry cover
Journal of Nutritional Biochemistry
IF:
4.9
Papers:
4.5K
Citations:
1.4W

Organization

Y
yanbian university
Scholars:
980
Papers: 286
Citations: 0
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