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Electrochemical Oxidative [3 + 2] Annulation of Enaminones and Phenols Toward 2-Amino-3-Aroylbenzofurans
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AI
L
L
H
Y
Z
J
DOI：10.1002/adsc.70601.png)
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Abstract
En 中文
An efficient electrochemical oxidative [3 + 2] annulation of enaminones and phenols has been developed for the synthesis of structurally diverse 2-amino-3-aroylbenzofurans in moderate to excellent yields. This protocol proceeds under mild, transition-metal, and oxidant-free conditions, exhibiting excellent substrate diversity and high functional group compatibility. Preliminary mechanistic studies suggest that the reaction involves a radical pathway initiated by anodic oxidation of the chloride ion. The Gram-scale synthesis and diverse transformations demonstrate the synthetic practicality.
Keywords:
annulation
benzofurans
electrosynthesis
enaminones
phenols
Journal
A
IF:
4
Papers:
424
Citations:
0