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Electrochemical Sensor Based on Molecularly Imprinted Polymer for Cefuroxime Detection in Biological and Environmental Samples
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DOI：10.1002/celc.70218.png)
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Abstract
En 中文
Cefuroxime (CFR), a widely used second-generation cephalosporin antibiotic, is increasingly detected in real samples due to its extensive use. Its presence raises concerns related to antimicrobial resistance and potential health risks, highlighting the urgent need for sensitive and selective detection. A novel electrochemical sensor based on a molecularly imprinted polymer (MIP) was developed for the selective detection of CFR. The MIP film was fabricated by electropolymerization of 3,4-ethylenedioxythiophene (EDOT) as the functional monomer and CFR as the template molecule, in the presence of gold nanoparticles (AuNPs) and titanium carbide MXene. The polymer was deposited onto a multiwalled carbon nanotube–modified screen-printed carbon electrode (SPE-MWCNT). The prepared sensor was characterized using scanning electron microscopy, cyclic voltammetry, and differential pulse voltammetry. Key experimental parameters, including monomer and template concentrations, number of polymerization cycles, template removal, and incubation time, were optimized. Under optimized conditions, the sensor exhibited a detection limit of 1.0 × 10−9 mol L−1 and a wide linear response range from 1.0 × 10−9 to 1.0 × 10−4 mol L−1 (logarithmic scale). The sensor was successfully applied to the determination of CFR in human serum and seawater samples, with recoveries ranging from 75.45% to 93.13% for human serum and 87.41% to 91.7% for seawater.
Keywords:
3,4-ethylenedioxythiophene
cefuroxime
molecularly imprinted polymer
multiwalled carbon nanotubes
titanium carbide MXene
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