.png){kind=icon}
.png){kind=icon}
Return
Electronically diverse carbenes
.png){kind=icon}
PRE
AI
DOI：10.1126/science.adz2592.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Cyclopropanes—three-membered rings of carbon atoms—are important building blocks in synthetic chemistry, especially in medicines. These molecules are rigid, have three-demensional architecture, and exhibit good metabolic stability (1—3). An important intermediate for generating cyclopropane is a carbene—a carbon atom with two single bonds and two free electrons. Carbenes dictate the resulting side group (substituent) attached to a cyclopropane. Hence, the classes of cyclopropanes that are accessible by chemical reaction are limited by carbenes. Certain substituents of cyclopropanes—such as amino, alkoxy, or polyalkyl groups—cannot be directly synthesized from a carbene and require multiple reaction steps. For example, ticagrelor, which is a drug used to prevent stroke and heart attack, contains a synthetically challenging aminocyclopropane (4, 5). On page 183 of this issue, Nguyen et al. (6) report a universal strategy to obtain electronically diverse carbenes that can produce a library of cyclopropanes.