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Electrophilic selenium drives electron leakage
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DOI：10.1016/j.chempr.2025.102499.png)
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Abstract
En 中文
Disrupting redox homeostasis in cancer cells represents a promising strategy for minimizing toxicity and improving chemotherapy outcomes. In Cell Biomaterials, Chen, Ma, and colleagues describe an approach that employs a selenium electrophilic center with rapid electron-shuttle properties to boost mitochondrial electron leakage and thus convert antioxidants into pro-oxidants for cancer therapy.