.png){kind=icon}
.png){kind=icon}
Return
Electrostatic Reinforcement of NIR-II Charge-Transfer Complexes for Durable Phototheranostics
.png){kind=icon}
PRE
AI
DOI：10.1002/adfm.202526483.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Intermolecular charge-transfer complexes (CTCs) are attractive for phototheranostics in the second near-infrared window (NIR-II) but suffer from intrinsic instability that undermines optical and therapeutic performance. Here, we introduce an electrostatic reinforcement-based supramolecular strategy to construct a stable NIR-II CTC, FBDFCTC nanoparticles (NPs), by co-assembling the NIR-II dye FBDF4NMe (donor) with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ, acceptor) at a ratio of 1:2. The resulting FBDFCTC NPs feature intense NIR-II absorption (ε1064 nm = 1.73 × 104 M−1 cm−1) and exceptional photothermal conversion efficiency (η = 56.3%) under 1064 nm irradiation. Beyond efficient photothermal therapy (PTT), the strong electrophilicity of F4TCNQ enables selective depletion of intracellular glutathione and cysteine, thereby amplifying oxidative stress and triggering exogenous iron-free ferroptosis. Notably, unlike conventional CTCs, FBDFCTC NPs retain robust NIR-II photothermal activity even after partial CTC dissociation, ensuring durable therapeutic performance in tumor environments. In vivo, FBDFCTC NPs afford high-contrast NIR-II photoacoustic imaging (PAI) for precise tumor localization and vascular mapping, followed by PAI-guided photothermal ablation. This work establishes electrostatic reinforcement of CTCs as a generalizable paradigm to achieve multifunctional NIR-II platforms that integrate deep-tissue PTT with tumor microenvironment modulation, opening new avenues for precise, durable, and safe cancer therapy.
Keywords:
charge-transfer complex
electrostatic interactions
ferroptosis
NIR-II
photothermal therapy
Journal
IF:
19
Papers:
3.4W
Citations:
32.1W