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Elevated serum miR-19a-3p as a diagnostic and prognostic biomarker for ischemic stroke: It aggravates neuronal injury through PTEN targeting
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DOI：10.1016/j.gene.2026.150272.png)
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Abstract
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• Serum miR-19a-3p is a high-accuracy diagnostic biomarker for ischemic stroke (AUC = 0.9213). • High miR-19a-3p independently predicts poor 90-day functional outcomes post-stroke. • miR-19a-3p inhibition reduces neuronal apoptosis, oxidative stress, and inflammation. • miR-19a-3p exacerbates ischemic injury by directly targeting the 3′UTR of PTEN.