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Emerging advantages of nano delivery systems in enhancing CAR-T/CRISPR-Cas9 mediated cancer therapeutics
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DOI：10.1016/j.bbcan.2026.189592.png)
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Abstract
En 中文
• Nano delivery systems significantly enhance the efficacy and safety of CAR-T and CRISPR-Cas9–based cancer therapeutics. • Nanocarriers enable targeted, non-viral delivery of CAR and CRISPR components, minimizing off-target effects and immunogenicity. • Integration of nanotechnology improves in vivo stability, transfection efficiency, and controlled release of gene-editing payloads. • Combined Nano-CAR-T and Nano-CRISPR approaches hold promise for overcoming tumor resistance, antigen escape, and toxic manifestations such as cytokine release syndromes. • Translational advancements in nanomedicine pave the way for next-generation, personalized cancer immunotherapy platforms.
Keywords:
Nano delivery systems
CAR-T therapy
CRISPR-Cas9
cancer therapeutics
nanomedicine
Journal
B
IF:
0
Papers:
105
Citations:
0
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