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Emerging microfluidic platforms for crystallization process development
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DOI：10.1016/j.cherd.2023.08.021.png)
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Abstract
En 中文
The microfluidic platform offers an exclusive environment compatible with different analytical tools to investigate crystallization processes. Moreover, microfluidic devices allow precise and convenient control of crystallization conditions at nano or meso scales, making them suitable for pharmaceutical and energy applications. These miniaturized screening devices can be effective during drug discovery stages for screening active ingredients available on micro/milligram scales. In this review, we discuss the advancements and applications of microfluidics platforms in the development of crystallization processes, including measurement of crystal growth and nucleation rates, screening of co crystals, polymorphs and morphology, synthesis of nanocrystals, and determination of metastable zones and solubility. In addition, the latest microfluidics setups for high throughput screening and lab-on-chip enhancements with sensors and automation are presented in this review. Lastly, an outlook on how microfluidic platforms can be adapted to improve workflow in crystallization process development is presented.(c) 2023 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.
Keywords:
Continuous crystallization
Polymorph screening
Growth rates
Crystal morphology
Lab-on-a-chip
Continuous-flow microfluidics
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