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Emerging Role of the cGAS–STING Signaling Pathway in Multiple Inflammatory Skin Diseases
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DOI：10.1155/dth/3322507.png)
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Abstract
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The cyclic GMP–AMP synthase (cGAS) –STING signaling pathway is a crucial regulator of inflammation, activated by misplaced genomic, mitochondrial, and microbial double-stranded DNA. It controls multiple physiological processes, including Type I interferon responses, autophagy, metabolism, cellular senescence, and programmed cell death. Dysregulation of this pathway is associated with a range of inflammatory, autoimmune, malignant, fibrotic, and neurodegenerative diseases.
Keywords:
cGAS–STING pathway
herpes virus
inflammatory skin diseases
psoriasis
rosacea
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