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Endocytic hierarchical miRNA-CaCO₃@PLGA nanoparticles: Intracellular Co-release of calcium ions /microRNA for enhanced traumatic brain injury neural stem cell therapy
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DOI：10.1016/j.nantod.2026.103116.png)
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Abstract
En 中文
• Hierarchical miRNA-CaCO₃@PLGA nanoparticles are nanoassembled with miR-124-loaded CaCO₃ cores encapsulated by PLGA. • Lysosomal pH-triggered CaCO₃ decomposition co-releases Ca²⁺ and miR-124 for synergistic pro-neurogenic effects. • In vitro, hierarchical miRNA-CaCO₃@PLGA nanoparticles enhance NSC neuronal differentiation to 32.4% vs 16.7% spontaneously. • Transplanted NSCs endocytosing miRNA-CaCO₃@PLGA nanoparticles promote cognitive and motor recovery in TBI mice.
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