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Endoscopic endonasal infrachiasmatic approach to intra-third ventricle craniopharyngiomas: surgical outcomes and limits to complete resection
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DOI：10.1007/s11102-026-01729-y.png)
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Abstract
En 中文
To evaluate the surgical outcomes of the endoscopic endonasal infrachiasmatic approach (EEIA) for intra-third ventricle craniopharyngiomas (IVC) and to define the anatomical limits of tumor resection through this corridor. We retrospectively analyzed 21 cases of IVCs (17 primary and 4 recurrent) who underwent EEIA between 2016 and 2025. Clinical data were obtained from the institution’s database. Surgical outcomes and anatomical limits of tumor resection were examined. Gross total resection (GTR) was achieved in 18 cases and subtotal resection (STR) in 3 cases. Among patients with preoperative visual and cognitive impairment, improvements were noted in 69.2% and 88.9%, respectively. Tumor margins extending beyond the anterior suprachiasmatic limit of visualization of the infrachiasmatic corridor (IC), corresponding to the chiasma-clival line (CCL), limited safe dissection. Furthermore, tumor adherence to adjacent vasculature and mammillary bodies represented an additional limitation. The EEIA may enable aggressive resection of IVCs while preserving and improving visual and cognitive function. Complete resection is limited by the geometry of the operative corridor and tumor adherence to vital structures. The CCL may serve as a practical marker of the anterior suprachiasmatic limit of the corridor and aid in preoperative planning, particularly in identifying cases that may require alternative or staged approaches.
Keywords:
Craniopharyngioma
Third ventricle
Endoscopic endonasal approach
Infrachiasmatic approach
Extent of resection
Surgical outcomes
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