.png){kind=icon}
Return
Endothelial Cell Function and Dysfunction in Critically Ill Children
.png){kind=icon}
OA
AI
DOI：10.1542/peds.2017-0355.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Endothelial cells (ECs) line the lumen of the entire vascular system and actively regulate blood flow; maintain blood fluidity; control water, solute, and macromolecular transfer between blood and tissue; and modulate circulating immune cell recruitment and activation. These vital functions, combined with the broad anatomic distribution of ECs, implicate them in all forms of critical illness. The present article discusses how ECs adapt and break down during the course of critical illness. We first review the biology of ECs, highlighting the vascular segmental differences and their specific roles in the maintenance of homeostasis. We then discuss how ECs acquire new functions to restore local and systemic homeostasis (activation) as well as how breakdowns in EC functions (dysfunction) contribute to local and systemic pathologic responses, with clinical correlations. Lastly, how these processes have been studied in critically ill children is discussed.
Keywords:
RESPIRATORY-DISTRESS-SYNDROME
INTERCELLULAR-ADHESION MOLECULE-1
PROTEIN-C
CARDIOPULMONARY BYPASS
SUBLINGUAL MICROCIRCULATION
COMPLEMENT ACTIVATION
ANGIOPOIETIN LEVELS
SEVERE SEPSIS
GROWTH-FACTOR
SEPTIC SHOCK
Journal
IF:
6.4
Papers:
2.4W
Citations:
7.8W
Organization
Cited Papers
ShareSaveShareSaveAdhesion molecules in pediatric intensive care patients with organ dysfunction syndrome.png)
INTENSIVE CARE MEDICINE
OAAI
INTENSIVE CARE MEDICINEIF21.2
OAAIShareSaveMonitoring the microcirculation in the critically ill patient: current methods and future approachesINTENSIVE CARE MEDICINE
INTENSIVE CARE MEDICINEIF21.2
PREAI
ShareSaveShareSave
View more