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Endothelial insulin-like growth factor 1 receptor-targeted vessel normalization potentiates neuroendocrine cancer immunotherapy
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DOI：10.1016/j.tips.2026.07.001.png)
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Abstract
En 中文
Angiogenesis fuels cancer progression, yet its immunomodulatory role in neuroendocrine malignancies remains poorly understood. Recently, Wang et al . identified a blood–brain barrier-like vascular gate that mediates immune exclusion and immunotherapy resistance in small-cell lung cancer. Targeting this barrier with OSI-906 enhances CD8+ T-cell infiltration and immunotherapy efficacy.
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