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Energy metabolic failure drives the selective degeneration of dopaminergic neurons in Parkinson’s disease
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DOI：10.1016/j.pnpbp.2026.111722.png)
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Abstract
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• Unique axonal architecture dictates high energy demand in dopaminergic neurons. • Impaired cellular bioenergetics precedes structural loss in Parkinson’s disease. • Energy metabolism failure contributes to Parkinson’s disease progression. • Metabolic pathways identified as targets for Parkinson’s disease therapy.
Keywords:
dopaminergic neurons
Parkinson’s disease
energy metabolism
bioenergetics
neuronal degeneration
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