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Engineered design of a pH-responsive, biocompatible Zn–MOF prodrug platform using 2-aminopurine anchoring as a pillar ligand
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DOI：10.1016/j.apmt.2026.103254.png)
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Abstract
En 中文
• The synthesis of a novel biocompatible MOF based on 2-aminopurine. • The synthesis of a pH-responsive prodrug with CHO modification of MTX and covalently attachment to the NH₂ groups of the bio-MOF. • The in vitro cumulative release evaluation in PBS solutions at pH of 5.0 and 7.4 to assess the role of the pH-sensitive CN bond.
Keywords:
biocompatible MOF
pH-responsive prodrug
2-aminopurine
Zn–MOF
drug delivery
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6.9
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3.2K
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