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Engineered Nanostructures for Sonothermal Therapy
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DOI：10.1002/adfm.202420859.png)
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Abstract
En 中文
Sonothermal therapy (STT) has become increasingly attractive recently as a noninvasive, safe, and nonionizing methodology. STT, as a newly emerging heat-enabled therapeutic approach, can rely on built-in bubble cavitation and thermal energy-electron recombination of sonothermal agents (STAs) activated by ultrasound (US) irradiation. In this domain, STT-enabled nanomedicine is considered a potential treatment for abnormal cell killing and normal cell renewing, which addresses the drawbacks of nonspecific heating in conventional microbubbles, side effects, and poor tissue penetration of available thermal-based therapies. Herein, a comprehensive review on the efficiency of STT in tumor ablation, infection therapy, and tissue regeneration is presented. Moreover, this review focuses on the benefits of STT as a therapeutic hot topic that can be used for nonantibiotic treatments, noninvasive heat-activated tissue regeneration, and highly efficient local cancer therapy. In addition, rational design of STAs, mechanistic innovations, and prospects of STT will also be provided.
Keywords:
cancer treatment
infection therapy
nanostructures
sonothermal therapy
Journal
IF:
19
Papers:
3.4W
Citations:
32.1W
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