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Engineered probiotics platform for resolvin E1 biosynthesis confers protection against inflammatory disease
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DOI：10.1002/ctm2.70746.png)
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Abstract
En 中文
The resolution of inflammation is actively driven by omega-3 polyunsaturated fatty acids (PUFAs) via their specialized pro-resolving mediator (SPM) derivatives, including resolvin E1 (RvE1), whose role has been well established. However, clinical application of these mediators is hampered by inherent instability and elevated production costs.
Keywords:
engineered probiotics
Escherichia coli Nissle 1917
gut microbiota
inflammation resolution
resolvin E1
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