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Engineering a heparin-mimetic biomaterial to promote tissue vascularization
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DOI：10.1038/s42003-025-08946-4.png)
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Abstract
En 中文
A major challenge in tissue engineering involves the development of synthetic biomaterials that effectively induce and maintain functional vascularization of engineered tissue constructs post implantation. While conjugating heparin to a dextran hydrogel developed a pro-angiogenic scaffold that led to substantial endothelial multicellular assembly in vitro and enhanced host vessel invasion in vivo, the inherent anti-coagulant bioactivities of native heparin elicited substantial local bleeding upon implantation. To decouple the pro-angiogenic effects from the anti-coagulant activity, we developed a synthetic, heparin-mimetic material by introducing sulfate adducts to the dextran backbone. These heparin-mimetic hydrogels bound and immobilized growth factors, enhanced angiogenic signaling, and promoted both in vitro vascular network formation in 3D and in vivo tissue microvascularization to a similar extent as heparin conjugated hydrogels, but without inducing local bleeding at implantation sites. This development of a fully synthetic, highly tunable angiogenic biomaterial provides a new material system to engineer functional vascularized tissues. Synthetic heparin-mimetic hydrogels immobilize angiogenic growth factors to promote tissue vascularization, providing salient properties of heparin-containing materials in promoting angiogenesis without the associated risk of bleeding.
Keywords:
Heparin-mimetic hydrogels
Angiogenesis
Tissue engineering
Vascularization
Biomaterials
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