.png){kind=icon}
.png){kind=icon}
Return
Engineering FeSe2@PDA-RGD Nanoplatform Integrating Redox Modulation and Immunoregulation for Enhanced Cutaneous Wound Healing
.png){kind=icon}
PRE
AI
H
S
A
Z
X
DOI：10.1142/S1793292026501031.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Chronic wounds are characterized by persistent oxidative stress, unresolved inflammation and impaired tissue remodeling, posing a major clinical challenge. Here, we report a bioinspired nanoplatform - polydopamine-coated, RGD-functionalized iron diselenide nanorods (FeSe2@PDA-RGD) - engineered to integrate antioxidant activity with immunoregulatory and pro-healing functions. FeSe2 nanorods serve as a sustained donor to support endogenous redox defense, while PDA enhances colloidal stability and biocompatibility, and surface RGD motifs promote cell adhesion and integrin-mediated crosstalk. Comprehensive physicochemical characterizations confirmed successful functionalization and stable nanostructures. In vitro, FeSe2@PDA-RGD effectively scavenged reactive oxygen species, reprogrammed macrophages toward an anti-inflammatory M2 phenotype, and modulated cytokine secretion Macrophage-endothelial coculture demonstrated enhanced HUVEC migration and VEGF expression, while macrophage-fibroblast coculture revealed increased fibroblast proliferation and migration. In vivo, FeSe2@PDA-RGD accelerated wound closure in a full-thickness murine skin model without detectable systemic toxicity, as evidenced by stable body weight, normal serum biochemistry, hematology and intact histology of major organs. Collectively, FeSe2@PDA-RGD establishes a favorable immune-redox microenvironment that promotes angiogenesis and tissue regeneration, highlighting its translational potential as an advanced therapeutic for chronic wound healing.
Keywords:
Selenium-based nanomaterials
wound healing
macrophage
polydopamine
RGD functionalization
Journal
IF:
1.1
Papers:
239
Citations:
1.7K
Organization
Cited Papers