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Engineering intrinsically disordered regions for guiding genome navigation
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DOI：10.1016/j.molcel.2026.01.019.png)
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Abstract
En 中文
• IDRs of native TFs direct genome binding • Activity of native IDRs depends on dispersed hydrophobic residues • Active IDRs can be designed de novo following simple design rules • Choice of hydrophilic residues tunes IDR binding specificity
Keywords:
IDRs
genome binding
hydrophobic residues
design rules
binding specificity
Journal
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