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Engineering piroxicam crystals with targeted morphologies and polymorphs using organic additives: A comprehensive study of tablet performance and molecular mechanisms
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DOI：10.1016/j.ejps.2026.107573.png)
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Abstract
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• Organic small molecules were adopted to regulate the crystal form and morphology of piroxicam. • Tablets made from modified piroxicam Form I exhibit an improved dissolution rate. • The regulatory mechanism of piroxicam morphology was elucidated at the molecular level.
Keywords:
Piroxicam
Organic small molecule additive
Crystal form regulation
Morphological modification
Tablet performance
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