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Enhanced tumor retention of the novel LAT1-targeting PET probe [18F]FAMT-OMe: A comparative study with [18F]FAMT in glioma mouse models
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DOI：10.1016/j.nucmedbio.2026.109623.png)
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Abstract
En 中文
[18F]fluoro-L-α-methyltyrosine ([18F]FAMT) has been reported as a positron-emission tomography (PET) probe that has high specificity for L-type amino acid transporter 1 (LAT1), which is overexpressed in various malignant tumors. However, [18F]FAMT showed rapid washout from the tumor and high retention in the kidney. This study aimed to develop and evaluate a novel LAT1-targeting PET probe, [18F]FAMT-OMe, and compare its performance with [18F]FAMT in glioma xenograft mice.
Keywords:
FAMT
LAT1
Oncology
PET
Small animal imaging
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