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Enhancing Analytical Separations Using Super-Resolution Microscopy
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DOI：10.1146/annurev-physchem-052516-045018.png)
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Abstract
En 中文
Super-resolution microscopy is becoming an invaluable tool to investigate structure and dynamics driving protein interactions at interfaces. In this review, we highlight the applications of super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and stationary-phase supports during chromatographic separations. Our discussion concentrates on the newfound ability of super-resolved single-protein spectroscopy to inform theoretical parameters via quantification of adsorption-desorption dynamics, protein unfolding, and nanoconfined transport.
Keywords:
industrial drug purification
chromatography
single-molecule spectroscopy
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