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Enhancing antitumor immunotherapy in head and neck cancer via ferroptosis-immune cascade activation by Fe-Shikonin nanomedicine

delete2026-04-30
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PRE
AI
S
Shengrui Gao
Y
Yu Wu
Z
Zhi Yu
M
Mingyang Lv
L
Ling Liu
Y
Yutong Liu
B
Bowen Chen
W
Wanzhong Yin *
DOI：10.1016/j.colsurfb.2026.115765delete
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Abstract

Abstract

En 中文
• Fe-Shikonin nanomedicine undergoes tumor microenvironment-responsive disassembly. • Fe²⁺ release amplifies ROS and lipid peroxidation to induce ferroptosis. • Ferroptotic stress triggers ICD and dendritic cell maturation. • Fe-Shikonin enhances CD8⁺ T-cell responses in HNSCC tumors. • scRNA-seq reveals enhanced antigen presentation and T-cell activation.
Keywords:
ferroptosis
immunotherapy
nanomedicine
tumor microenvironment
T-cell activation

Journal

C
Colloids and Surfaces B: Biointerfaces
IF:
5.6
Papers:
1.4W
Citations:
4.2W

Organization

J
Jilin University
Scholars:
8.4W
Papers: 5.5W
Citations: 8.9K
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