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Entropy-driven segregation and budding in hybrid vesicles of binary nanoparticle amphiphiles
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DOI：10.1016/j.giant.2020.100010.png)
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Abstract
En 中文
Self-assembly of giant building blocks beyond conventional molecules offers tremendous opportunities for the fabrication of new-generation structural materials. This work describes the macroscopic colloidal segregation in the vesicular self-assembly of binary nanoparticle amphiphiles (NPAMs) consisting of block copolymer-grafted nanoparticles in solution. Depending on their relative size and concentration, binary NPAMs with distinctive sizes assemble into hybrid vesicles with different morphologies, namely, homogeneous vesicles, patchy vesicles, and yolk/shell vesicles. The segregation of NPAMs confined within or escaped from the vesicular membrane is driven by the conformational entropy gain of endgrafted copolymer ligands. The effect of NPAM size and concentration on the morphological transition of vesicles is mapped in a phase diagram. Moreover, a vesicular fusion/budding mechanism is proposed to illustrate the formation of uniform vesicles with yolks inside. The hybrid vesicles have potential applications in cancer imaging, biosensing, and drug delivery.
Keywords:
Self-assembly
Polymer ligands
Gold nanoparticles
Vesicles
Segregation
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