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Epigenetics and Exercise
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DOI：10.1016/j.tem.2019.06.002.png)
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Abstract
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Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.' Increased transcription of key regulatory, metabolic, and myogenic genes is an early response to exercise and is important in mediating subsequent adaptations in skeletal muscle. DNA hypomethylation and histone hyperacetylation are emerging as important crucial events for increased transcription. The complex interactions between multiple epigenetic modifications and their regulation by metabolic changes and signaling events during exercise, with implications for enhanced understanding of the acute and chronic adaptations to exercise, are questions for further investigation.
Keywords:
ACTIVATED PROTEIN-KINASE
HUMAN SKELETAL-MUSCLE
ACETYL-COA CARBOXYLASE
DNA METHYLATION
HISTONE H3
MESSENGER-RNA
METABOLISM
AMPK
REVEALS
PHOSPHORYLATION
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MOLECULAR CELL
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MOLECULAR CELLIF16.6
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