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Epileptogenesis
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DOI：10.1101/cshperspect.a022822.png)
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Abstract
En 中文
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.
Keywords:
TEMPORAL-LOBE EPILEPSY
TRAUMATIC BRAIN-INJURY
DENTATE GRANULE CELLS
SPONTANEOUS RECURRENT SEIZURES
CONTROLLED CORTICAL IMPACT
INDUCED STATUS EPILEPTICUS
FLUID PERCUSSION INJURY
MIDDLE CEREBRAL-ARTERY
SPRAGUE-DAWLEY RATS
TERM VIDEO-EEG
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