.png){kind=icon}
Return
Epithelial cell division - multiplying without losing touch
.png){kind=icon}
OA
AI
DOI：10.1242/jcs.151472.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed and stabilized by Ecadherin and catenin proteins linked to the actomyosin cytoskeleton. During development and throughout adult life, epithelia are continuously growing or regenerating, largely as a result of cell division. Although persistence of adherens junctions is needed for epithelial integrity, these junctions are continually remodelled during cell division. In this Commentary, we will focus on cytokinesis, the final step of mitosis, a multiparty phenomenon in which the adherens junction belt plays an essential role and during which a new cell-cell interface is generated between daughter cells. This new interface is the site of intense remodelling, where new adhesive contacts are assembled and cell polarity is transmitted from mother to daughter cells, ultimately becoming the site of cell signalling.
Keywords:
Epithelial cells
Adherens junctions
Cytokinesis
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.6
Papers:
1.1W
Citations:
3.7W
Organization
Cited Papers
ShareSaveMammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.png)
NATURE CELL BIOLOGYOAAI
NATURE CELL BIOLOGYIF19.1
OAAIShareSaveShareSaveShareSaveUnequal segregation of neuralized biases notch activation during asymmetric cell divisionDEVELOPMENTAL CELL
OAAI
DEVELOPMENTAL CELLIF8.7
OAAIShareSaveAnillin and the septins promote asymmetric ingression of the cytokinetic furrowDEVELOPMENTAL CELLOAAI
DEVELOPMENTAL CELLIF8.7
OAAIShareSaveSeptins promote F-actin ring formation by crosslinking actin filaments into curved bundlesNATURE CELL BIOLOGY
NATURE CELL BIOLOGYIF19.1
PREAI
ShareSave
View more