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ER-localized ceramide accumulation contributes to replicative senescence
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DOI：10.1016/j.chembiol.2026.03.003.png)
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Abstract
En 中文
• Replicative senescence features ceramide accumulation with depletion of sphingomyelins • Sphingomyelin depletion despite unchanged SMS activity suggests impaired ceramide flux • CERT inhibition phenocopies senescence • Ceramides accumulate at the ER in senescent cells
Keywords:
ceramide
sphingomyelin
replicative senescence
ER
CERT
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