.png){kind=icon}
.png){kind=icon}
Return
Ethanol exacerbates post-burn neuroinflammation and gut–brain barrier dysfunction which are associated with microbiome changes.
.png){kind=icon}
PRE
AI
R
M
K
D
J
E
DOI：10.1016/j.alcohol.2026.04.007.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Acute ethanol exposure prior to burn injury potentiates neuroinflammation and enhances inflammatory gene expression in microglia. • The combined insult of ethanol exposure and burn injury disrupt intestinal and blood–brain barrier integrity, increasing bacterial translocation and brain albumin accumulation. • Dysbiosis of the gut microbiome links peripheral injury to neuroinflammation, highlighting the gut–brain axis as a therapeutic target. • Findings support a mechanistic role of the gut–brain axis in linking ethanol intoxication with worsened neuroinflammatory outcomes after burn injury.
Keywords:
Ethanol
Burn injury
Neuroinflammation
Gut-brain axis
Microbiome
Journal
IF:
2.9
Papers:
192
Citations:
3.1K
Organization
Cited Papers